Proteoforms: A Matter of Preservation in Proteomics


  • Date
    June 7, 2017
  • Time
    8:00 a.m. PDT / 11:00 a.m. EDT / 16:00 BST / 17:00 CEST - Duration: 60 Minutes

Date : June 7, 2017
Time : 8:00 a.m. PDT / 11:00 a.m. EDT / 16:00 BST / 17:00 CEST - Duration: 60 Minutes
  • Overview

    Proteins are highly versatile macromolecules that enact a wide range of biological functions such as catalysis, regulation, communication, mechanical support, movement, and transport. At least several million unique proteins exist in the human body which are, surprisingly, encoded by only fifteen thousand genes. The divergent number of proteins compared to genes is due to protein variants, or “proteoforms”, that originate from a single gene as unique combinations of amino acid sequence variations (e.g. alternative splicing or endogenous proteolytical processing) and/or post-translational modifications. It is important to note that out of all possible proteoforms from a single coding gene only one or a few may correlate with (disease) biology. Read more

    Brought to you by:
  • Speakers

    Hans Wessels,
    Proteomics Scientist,
    Radboudumc
    Britt Erikson,
    Senior Editor,
    C&EN