Dynamic Light Scattering (DLS) is the most widely employed technique for size and polydispersity measurement in protein, polymer, and nanoparticle research. Traditionally, DLS has been limited to measuring a single sample at one time in a cuvette, but the DLS Plate Reader from Wyatt breaks through this limitation by measuring entire well plates of samples at one time. This expanded measurement capacity combined with small volume requirement and flexible, custom experiment design enable analyses that were not previously possible.