Biological and Medicinal Chemistry

A Cornucopia of Catalytic Commitments to Drive the MSD Portfolio

New photochemical methods in halogen-atom transfer chemistry

1. Chem. Rev. 2022, 122, 2292
2. (a) Science 2020, 367, 1021; (b) Org. Lett. 2022, 24, 7883; (c) ACS Catal. 2023, 13, 4985.

Catalysis with Earth Abundant Metals as an Enabling Tool for Chemical Synthesis

Simplifying Synthesis with Electricity

1. Gao, Y; Zhang, B; He, J; Baran, P. S. Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(sp3)–C(sp3) Cross Coupling. J. Am. Chem. Soc. 2023, 145, 21, 11518-11523 
2. Laudadio, G.; Palkowitz, M. D.; Ewing, T. E.-H.; Baran, P. S. Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry. ACS Med. Chem. Lett. 2022, 13, 9, 1413 – 1420 
3. Hayashi, K.; Griffin, J.; Harper, K. C.; Kawamata, Y.; Baran, P. S. Chemoselective, Metal-free, (Hetero) Arene Electroreduction Enabled by Rapid Alternating Polarity. J. Am. Chem. Soc. 2022, 144, 13, 5762 – 5768 

Unlocking The Photocatalytic Functionalities Of Polycyclic Heteroaromatics Through Oxidation Reactions  

New Strategies and Tactics in Natural Products Synthesis

1. Classen, M. J.; Kicin, B.; Ruf, V. A. P.; Hamminger, A; Ribadeau-Dumas, L.; Amberg, W. M.; and Carreira, E. M. Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade J. Am. Chem. Soc. 2023 doi: 10.1021/jacs.3c11000
2. Bulthaupt, H.; Glatz, F.; Papidocha, S. Wu, C.; Teh, S.; Wolfrum, S.; Balazova, L; Wolfrum, C; Carreira, E. M. Enantioselective Total Syntheses of Cassane Furanoditerpenoids and their Stimulation of Cellular Respiration in Brown Adipocytes" J. Am. Chem. Soc. 2023, doi: 10.1021/jacs.3c07597
3. Papidocha, S. M., Bulthaupt, H.; and Carreira, E. M. Synthesis of Neocaesalpin A, AA, and Nominal Neocaesalpin K; Angew. Chem. Int. Ed., 2023, e202310149.
4. Fadel, M., Carreira, E. M. Enantioselective Total Synthesis of (+)-Pedrolide; J. Am. Chem. Soc. 2023, 145, 8332-8337; doi: 10.1021/jacs.3c02113.
5. Classen, M.; Boecker, M.; Roth, R.; Amberg, W. M.; Carreira, E. M., Enantioselective Total Synthesis of (+)-Euphorikanin A J. Am. Chem. Soc. 2021, 143, 8261-8265.

Catalysis via Gold(I) Carbenes

1. (a) Dorel, R.; Echavarren, A. M. Chem. Rev. 2015, 115, 9028–9072. (b) Echavarren, A. M.; Muratore, M. N.; López-Carrillo, V.; Escribano-Cuesta, A.; Huguet, A.; Obradors, C. Org. React. 2017, 92, 1–288.
2. Scharnagel, D.; Escofet, I.; Armengol-Relats, H.; De Orbe, M. E.; Korber, J. N.; Echavarren, A. M. Angew. Chem. Int. Ed. 2020, 59, 4888–4891.
3. Medina, T.; Sadurní, A.; Hammarback, L. A.; Echavarren, A. M. ACS Catal. 2023, 13, 10751–10755.

Catalysis to increase complexity: stereoselective synthesis of sp3-rich building blocks

1. Selected references: a) Teresa, J.; Velado, M.; Fernández de la Pradilla, R.; Viso, A.; Lozano, B.; Tortosa, M. Chem. Sci. 2023,14, 1575. (b) Nóvoa, L.; Trulli, L.; Parra, A.; Tortosa, M. Org. Lett. 2021, 23, 7434. (c) Nóvoa, L.; Trulli, L.; Parra, A.; Tortosa, M. Angew. Chem. Int. Ed. 2021, 60, 11763. (d) Amenós, L; Novoa, L.; Trulli, L.; Arroyo-Bondía, A.; Parra, A.; Tortosa, M., ACS Catal. 2019, 9, 6583-6587. (d) Amenós, L.; Trulli, L.; Nóvoa, L.; Parra, A.; Tortosa, M. Angew. Chem. Int. Ed. 2019, 58, 3188. (e) Guisan-Ceinos, M.; Martin-Heras V.; Tortosa M. J. Am. Chem. Soc. 2017, 139, 8448-8451.

Accelerating Advances in Catalysis – Concepts, Insights, Strategies

1. Fricke, C.; Sperger, T.; Schoenebeck, F. Angew. Chem. Int. Ed. 2021, 60, 3355.
2. Kapat, A.; Sperger, S.; Guven, S.; Schoenebeck, F. Science 2019, 363, 391.
3. Dahiya, A.; Gevondian, A. G.; Schoenebeck, F. J. Am. Chem. Soc. 2023, 145, 7729.
4. Hueffel, J.; Sperger, T.; Funes-Ardoiz, I.; Ward, J.; Rissanen, K.; Schoenebeck, F. Science 2021, 374, 1134.

Peptide and Protein Catalysts with Enzyme-like Properties

Metal- or metal-free? Complementarity towards the sustainable synthesis of complex molecules via C-H functionalization.

1. T. Rogge, N. Kaplaneris, N. Chatani, J. Kim, S. Chang, B. Punji, L. L. Schafer, D. G. Musaev, J. Wencel-Delord, C. A. Roberts, R. Sarpong, Z. E. Wilson, M. A. Brimble, M. J. Johansson, L. Ackermann, Nat Rev Methods Primers 2021, 1, 43.
2. a) N. Jacob, Y. Zaid, J. C. A. Oliveira, L. Ackermann, J. Wencel-Delord, J. Am. Chem. Soc. 2022, 144, 798–806. b) A. Luc, J. C. A. Oliveira, P. Boos, N. Jacob, L. Ackermann, J. Wencel-Delord, Chem Catalysis 2023, 3, 100765.
3. a) M. Lanzi, Q. Dherbassy, J. Wencel‐Delord, Angew. Chem. Int. Ed. 2021, 60, 14852–14857. b) M. Lanzi, T. Rogge, T. S. Truong, K. N. Houk, J. Wencel-Delord, J. Am. Chem. Soc. 2023, 145, 345–358. c) M. De Abreu, T. Rogge, M. Lanzi, T. Saiegh, K. N. Houk, J. Wencel-Delord, Angew. Chem. Int. Ed. 2024, doi: 10.1002/anie.202319960

Catalytic regulation of chemical reaction networks