C&EN App Note
Online Reaction Monitoring of Aspirin Hydrolysis
Brought to you by Agilent Technologies

In modern production of small molecule pharmaceuticals and biopharmaceuticals, the reaction must be closely monitored and potentially even controlled by online reaction monitoring analytics.

This application note demonstrates the use of the Agilent InfinityLab Online LC Solution for monitoring reactions with different reaction speeds. The method requires high sampling speeds for sampling and quenching, as well as direct injection for the fastest results. As a model reaction, the pH-dependent hydrolysis of acetylsalicylic acid (Aspirin) to salicylic acid has been used.

Key Objectives:
  • How to set up the HPLC instrument for an online LC experiment
  • How to set up the Agilent Online LC Monitoring Software to orchestrate the experiment
  • How to display experimental results in the Online LC Monitoring Software

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