Online Reaction Monitoring of Aspirin Hydrolysis

Online Reaction Monitoring of Aspirin Hydrolysis

Brought to you by Agilent Technologies

Overview

In modern production of small molecule pharmaceuticals and biopharmaceuticals, the reaction must be closely monitored and potentially even controlled by online reaction monitoring analytics.

This application note demonstrates the use of the Agilent InfinityLab Online LC Solution for monitoring reactions with different reaction speeds. The method requires high sampling speeds for sampling and quenching, as well as direct injection for the fastest results. As a model reaction, the pH-dependent hydrolysis of acetylsalicylic acid (Aspirin) to salicylic acid has been used.

Key Objectives:

How to set up the HPLC instrument for an online LC experiment
How to set up the Agilent Online LC Monitoring Software to orchestrate the experiment
How to display experimental results in the Online LC Monitoring Software

Brought to you by:

Please complete the form to download the app note.

Forwarded this link? Clear the form

Email Address*

Salutation*

First Name*

Last Name*

Company*

Job Level

Address 1*

City*

State*

Zip / Post Code*

Country*

Business Phone*

Agilent wants to keep in touch with you. Please let us know your preference.

Yes, I would like to be contacted via phone or email by an Agilent representative.

Yes, I would you like to receive email information from Agilent about products, services and events. For full details of how Agilent will treat your information please view Agilent’s privacy policy, https://www.agilent.com/home/privacy-policy

I would like to receive more information on products and services from the American Chemical Society

*By submitting this form, you agree to receive more information on related products and services from the American Chemical Society (ACS Publications) and its sponsor via email. ACS takes your privacy seriously. For more information, please see the ACS Privacy Policy .