Automated Isolation and Reanalysis of Impurities

Overview

Isolation of impurities for further characterization is a routine task in the pharmaceutical industry and is often performed using preparative high performance liquid chromatography (HPLC). Usually, some steps of the workflow require manual interaction, making the whole process time-consuming and error-prone.

This application note demonstrates how automation can help to accelerate the workflow and eliminate error sources. The presented workflow includes method development on an analytical scale, upscaling to preparative conditions, fraction collection, and fraction reanalysis.

Key Objectivesï¼š

Scaling an analytical method to preparative conditions
Overloading the preparative column for higher yield
Selecting fractions for automated homogenization and reanalysis
The importance of reanalyzing fractions

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