Continuous chromatography (MCSGP) technology represents great progress in the downstream processing for peptide and oligonucleotide manufacturing. Compared to single-column batch purification, solvent consumption is typically decreased by more than 30% using MCSGP, thus contributing to higher sustainability. Furthermore, this innovative technology leads to an attractive economic benefit due to its automated way of manufacturing. In regular batch purifications, achieving the APIâ€™s target purity and impurity profile often comes with a decrease of yield and productivity. In contrast, MCSGP runs 24/7 providing high product yield without adverse impact on purity and impurity profile. Savings in cycle time can reach up to 70%, depending on the compared batch chromatography.