C&EN White Paper
Pushing the boundaries of peptides and oligonucleotides purification
Brought to you by Bachem AG

Continuous chromatography (MCSGP) technology represents great progress in the downstream processing for peptide and oligonucleotide manufacturing. Compared to single-column batch purification, solvent consumption is typically decreased by more than 30% using MCSGP, thus contributing to higher sustainability. Furthermore, this innovative technology leads to an attractive economic benefit due to its automated way of manufacturing. In regular batch purifications, achieving the API’s target purity and impurity profile often comes with a decrease of yield and productivity. In contrast, MCSGP runs 24/7 providing high product yield without adverse impact on purity and impurity profile. Savings in cycle time can reach up to 70%, depending on the compared batch chromatography.

Key Objectives:

In this whitepaper, you will understand the key benefits of continuous chromatography (MCSGP) for API purification:
  • MCSGP deploys standard RP and AEX chromatographic conditions, and API quality (defined such as purity, impurity profile, counter ion content, etc) is not adversely affected
  • MCSGP is a scalable, highly efficient and cost-effective process – particularly for large-scale production
  • MCSGP is an automated system, which can run 24/7, allowing a significant decrease in the purification campaign cycle times
  • MCSGP is a more sustainable process. It reduces solvent consumption and process mass intensity (PMI)

Brought to you by:
Bachem AG
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