Biochemistry of Pain: A virtual event

Biochemistry of Pain

A Virtual Event

Available On-Demand

Biochemistry of Pain: A Virtual Event

Biochemistry is pleased to announce the Biochemistry of Pain virtual event to complement our special virtual issue on this same topic. During this event exciting new research was discussed that expands our fundamental understanding of pain, as well as how it can be safely and effectively treated.

Watch the event on-demand to hear from our distinguished speakers; Bryan Roth (University of North Carolina Chapel Hill), Lakshmi Devi (Icahn School of Medicine), Avi Ma'ayan (Icahn School of Medicine), and Laura Bohn (Scripps Research Institute).

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Who you'll hear from:

Bryan Roth

University of North Carolina, Chapel Hill

Bryan Roth – Michael Hooker Distinguished Professor of Pharmacology, UNC Department of Pharmacology; Research Professor, UNC Department of Psychiatry; Professor, UNC Eshelman School of Pharmacy; Director, NIMH Psychoactive Drug Screening Program. He is a Member of the National Academy of Medicine of the National Academy of Sciences, and a Fellow of the American Academy of Arts and Sciences. He has published >450 papers, with >60,000 citations (via Google Scholar), he is listed as an inventor on >40 published/submitted US, WO and foreign patents.

The Roth Lab studies the structure and function of G-protein coupled receptors (GPCRs) and is the principal contractor for the NIMH Psychoactive Drug Screening Program. GPCRs represent one of the most evolutionarily diverse superfamilies of the human genome. The Roth Lab has pioneered the use of directed molecular evolution to create GPCRs that are suitable for remotely controlling cellular signaling. Using a variety of mouse genetic approaches, the lab is able to control neuronal firing and non-neuronal signaling in real-time in awake, freely moving animals. This technology has afforded the scientific community the opportunity to discover how cell-type specific modulation of signaling is translated into behavioural and non-behavioural outcomes.

Lakshmi Devi

Icahn School of Medicine

Dr. Devi is Professor of the Pharmacology and Systems Therapeutics, Psychiatry and Neuroscience departments. She is the Dean for Academic Development and Enrichment as well as Director of the Interdisciplinary Training in Drug Abuse Research Program.

Throughout her career, she has been interested in several lines of research, including receptor dimerization, regulation of peptide biosynthesis and opiate addiction. Part of her research focus is to explore mechanisms underlying opiate and cannabinoid receptor activation using a combination of molecular biological, biochemical, cell biological, pharmacological and behavioral techniques. Some of the projects in her lab also use a combination of classic and modern techniques in molecular pharmacology to explore the novel pharmacology of receptor heterodimers, and/or cutting-edge neuroproteomic techniques to analyze morphine induced changes in the levels of synaptic proteins and neuropeptides.

Avi Ma'ayan

Icahn School of Medicine

Dr. Ma’ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences and Director of the Mount Sinai Center for Bioinformatics. Dr. Ma'ayan is also Principal Investigator of the NIH-funded BD2K-LINCS Data Coordination and Integration Center and Mount Sinai Knowledge Management Center for Illuminating the Druggable Genome.

The Ma'ayan Laboratory applies computational and mathematical methods to study the complexity of regulatory networks in mammalian cells. His research team applies machine learning and other statistical mining techniques to study how intracellular regulatory systems function as networks to control cellular processes such as differentiation, dedifferentiation, apoptosis and proliferation. The Ma'ayan Laboratory develops software systems to help experimental biologists form novel hypotheses from high-throughput data, while aiming to better understand the structure and function of regulatory networks in mammalian cellular and multi-cellular systems.

Laura Bohn

Scripps Research Institute

Laura M. Bohn, Ph.D. is a Professor of Molecular Medicine and Neuroscience at The Scripps Research Institute in Jupiter, FL where she is endowed by the Dembling Fund for Drug Discovery and Human Health Research. She is actively pursuing new therapies for the treatment of pain and addiction by modulating G protein-coupled receptors which are critically involved in how patients respond to many therapeutics, including opioid analgesics.

Dr. Bohn earned degrees in Chemistry and Biochemistry from Virginia Tech and a PhD in Biochemistry and Molecular Biology from St. Louis University School of Medicine with Dr. Carmine Coscia. She completed post-doctoral training at Duke University Medical Center in the laboratory of Dr. Marc Caron in collaboration with Dr. Robert Lefkowitz. Dr. Bohn was a tenured Associate Professor of The Ohio State University College of Medicine in the Departments of Pharmacology and Psychiatry before she joined TSRI in 2009. She has received a young investigator award from the Society for Neuroscience, the Joseph P. Cochin Award from CPDD, the Viktor Mutt Lectureship from the International Regulatory Peptide Society, and the John J. Abel Award in Pharmacology from the ASPET. Her research program is funded by the National Institutes on Drug Abuse.