In recent years, successful miniaturization and automation of assays have reduced the scale of synthesis in drug discovery. This has enabled faster analysis, higher throughput, and reduced material consumptionâ€”lowering the cost per experiment without compromising data quality.
The purification of compounds of interest is a critical step in the library synthesis and purification process. It requires a robust, high-throughput, microgram-scale workflow.
This webinar demonstrates the development of such an end-to-end workflow. UHPLC/MS instrument optimization, column selection, column loading studies, and the benefits of ultrafast pre- and post-purification analysis will be highlighted.
Key Learning Objectives:
- How to optimize a microgram-scale UHPLC/MS purification instrument for high purity and recovery
- How to achieve higher throughput and faster turnaround times when purifying microgram-scale reactions
Who Should Attend:
- Laboratory managers