Recent Advances in Oligo Purity and Sequence Determination by LCMS

DATE

January 19, 2023

TIME

8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET - Duration: 60 Minutes

Overview

Oligonucleotides (oligos) have become fast-growing modalities in recent years. Along with the development of these candidates has come the increased need for robust analytical methods and easy-to-use data analysis workflows to characterize them. Critical quality attributes of oligos include their mass, purity, and sequence â€“ each of which can be difficult, time consuming, and tedious. As such, software that supports these efforts can be of great value. In this work, we present novel, automated, and integrated software to support these workflows using LC HRAM MS instruments. Purity and sequencing data are presented for a multitude of oligos including antisense, aptamer, and long synthetic samples.

Key Learning Objectives:

Techniques for analyzing the critical quality attributes (CQAs) of oligos â€” including their mass, purity, and sequence
How novel, automated, and integrated software can facilitate the analysis of oligo CQAs using LCâ€“HRAM MS instruments.
Purity and sequencing data for a multitude of oligos including antisense, aptamer, and long synthetic samples

Who Should Attend:

Researchers analyzing the critical quality attributes (CQAs) of oligos â€” including their mass, purity, and sequence
Chromatographers
Researchers interested in using LCâ€“HRAM MS instruments for determination of oligo mass, purity and sequence

Brought to you by:

Speakers

Peter Rye
Application Engineer Pre Sales,
Agilent Technologies

Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group

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