Analytical Strategies for Complete Characterization and Purification of Synthetic Oligonucleotides

February 16, 2023
8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET - Duration: 60 Minutes


Synthetic oligonucleotides have become the fast-growing therapeutic modality in recent years and are being increasingly developed for treating a wide range of disease conditions. Along with the development of these therapeutic candidates comes the increased need for reliable analytical methods and easy-to-use data analysis workflows to fully characterize them to ensure the intended efficacy. Thus, reliable and sensitive analytical and preparative methods are required to adequately resolve impurities and establish purity and identity of the intended oligonucleotide product.

In this presentation, we will present the relevant chromatography, mass spectrometry and spectroscopy based analytical strategies to confidently detect, quantify and purify oligonucleotides and their related impurities that can help you meet both the challenges of synthetic oligonucleotide quality assessment, and the productivity needs of your lab.

Key Learning Objectives:
  • Learn about the manufacturing challenges associated with synthetic oligo drugs
  • Learn about the critical quality attributes for complete assessment of synthetic oligonucleotides
  • Learn about the analytical approaches for the confident identification, quantification and purification of synthetic oligonucleotides and the related impurities
Who Should Attend:
  • Laboratory managers
  • Chromatographers
  • New product developers

Brought to you by:
Agilent Technologies


Parul Angrish, Ph.D.
Biopharma/Pharma Market
Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group


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