Ion Mobility Mass Spec - A 4th Dimension Gets More Information Faster Than Ever Before

DATE

March 10, 2022

TIME

8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET

Duration: 60 Minutes

Overview

Ion mobility is fast becoming mainstream. In this webinar, you will learn how Ion Mobility addresses current problems in the characterization of complex biomolecules. Ion Mobility adds another dimension of separation, allowing the detection of different molecular structural elements that would remain unseen by conventional mass spectrometry alone.

This webinar will demonstrate unique capabilities in separation and analysis using a low-field drift-tube based separation with Collision-induced unfolding (CIU), and the novel SLIM (Structures for Lossless Ion Manipulations) technology with highest full spectrum Ion Mobility resolution by incorporating a 13m non-linear ion path into a benchtop instrument. Focusing on Biopharma applications, this webinar will show how utilizing Ion Mobility can be used to obtain an in-depth understanding of the most challenging analyses.

Key Learning Objectives:

Principles of Ion Mobility and the separation by shape
Drift tube ion mobility
Structures for Lossless Ion Manipulation (SLIM) technology and high-resolution ion mobility (HRIM)
Collisional Cross Section (CCS) as an inherent chemical property to measure and exploit
Collision induced unfolding (CIU) to understand protein stability and changes
Fast separation and characterization of Glycans
Ultra-high resolution Ion Mobility by miniaturized SLIM technology
Separation of deamidated peptides using high-resolution Ion Mobility
Validated workflows for MOBIE, highlighting real-world data
Intact/subunit protein analysis
Peptide analysis
Released glycan analysis
Targeted lipid analysis
Benefit of adding a new separation dimension to MS workflows
Reduced reliance on traditional chromatography
High-throughput analysis of biologically relevant molecules in seconds
High resolution separation of isobaric and isomeric species

Who Should Attend:

Biopharma Analytical Scientists
Lab Managers
Principle Investigators
Life Science Researchers
Directors of biopharma research
Discovery/R&D research scientists
Early development/analytical development scientists
Process development, process analytical support scientists
Mass Spectrometry core lab directors, scientists, and technicians
Professors, post-docs, and graduate students utilizing mass spectrometry

Brought to you by:

Speakers

Chris Klein
LC/Q-TOF Product Manager,
Agilent Technologies

Tom Doherty
Senior Product Manager,
MOBIEÂ®, MOBILion Systems, Inc.,

Kelly McSweeney
Contributing Editor,
C&EN Media Group

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