The process of drug discovery and development is a path that enlists the expertise of many while in pursuit of the one novel entity that rises above a host of potential candidates. For peptides this can be a daunting task given molecule complexity, physiochemical properties, receptor selectivity and scale-up of material. This presentation will discuss the discovery of our Glucagon agonist and how to use innovative technologies, focused SAR, and effective integration of a unique multidisciplinary team in the drug discovery process.