Cold probe technology offers significant sensitivity enhancements over traditional room temperature probes. Using liquid nitrogen as the cryogen affords greatly reduced operational costs compared to Helium cryostat probes. Another excellent choice with low running costs and slightly better performance is a closed cycle Helium cooler running at 50 kelvin. Basically by reducing thermal noise these probes can reduce experiment time by a factor of about 9 with no loss of experiment flexibility.

Examples of very modern 1 and 2 dimensional NMR data acquired with a fully broadband nitrogen cooled probe will be presented and by example illustrate robust approaches to solving common difficult and interesting strucure problems. Measurements tradiionally difficult to access such as carbon-carbon direct and long-range coupling pathways and J values, now very useful in computational chemistry, are shown to be easily accessible by simple 1 dimensional experiments.