C&EN Webinars

Probing Metabolite Utilization and Growth in Pathogenic Microbes

May 17, 2022
8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST
Duration: 60 Minutes


A sub-class of pathogenic microbes exhibit drastically increased biomass accumulation when supplemented with short chain fatty acids (SFCAs). This phenomenon was probed via untargeted stable isotope labeling metabolomic studies leveraging Thermo Scientificâ„¢ Compound Discovererâ„¢ software. Metabolites presenting fold changes as well as downstream isotopic enrichment from a 13 C 2 acetate substrate were used to inform on this unusual phenomenon and increase our understanding of the microbe's pathogenic mechanism.

Key Learning Objectives:
  • Understand how to study biological metabolism with liquid chromatography-mass spectrometry
  • Learn how to perform untargeted stable isotope labeling experiments
  • See advanced tools for analyzing and reporting untargeted stable isotope labeling data
Who Should Attend:
  • Scientists interested in metabolomics and stable isotope labeling
  • Analytical chemists
  • Scientists interested in studying biological processes

Brought to you by:
Thermo Fisher Scientific


Juan Moises Sanchez
Chan Zuckerberg Biohub at Stanford University
Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group


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