Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

DATE

January 25, 2023

TIME

8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET - Duration: 60 Minutes

Overview

Proteolysis-targeting chimeras (PROTACs) are a class of bifunctional molecules which are enabling the development of drugs against targets once considered inaccessible. PROTACs bring a protein of interest into close-proximity to an E3 ubiquitin ligase, resulting in the degradation of the target protein by the ubiquitin-proteasome system. The design, synthesis, and optimization of PROTACs can be quite challenging due to their complicated mechanism of action and relatively high molecular weight and size.

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify binders of target proteins. These topics will be discussed within the context of PROTAC lead optimization.

Key Learning Objectives:

Leveraging DNA-encoded libraries (DEL) to identify binders to target proteins
Accelerating the optimization of PROTACs towards preclinical candidate selection
PROTAC Discovery and Chemistry Workflows

Who Should Attend:

Scientists and researchers interested in protein degradation workflows

Brought to you by:

Speakers

Kris Rutten
Director,
WuXi AppTec

Jason Deng
Senior Director, DEL Biology,
WuXi AppTec

Lei Zhou
Executive Director,
WuXi AppTec

Ann Thayer
Contributing Editor,
C&EN Media Group

Registration

Forwarded this event? Clear the form

Email Address*

Salutation

First Name*

Last Name*

Company*

Job Title*

Address 1*

City*

State*

Zip / Post Code*

Country*

Business Phone*

Yes, we are interested in identifying and developing bifunctional molecules to support our drug discovery programs

We are interested in learning about the challenges in the design of PROTACs, and how to optimize the synthesis and linker design of these molecules

We would like to learn about the use of DNA-encoded library (DEL) screening as an affinity selection method for ligand finding in PROTAC drug discovery

I would like to receive more information on products and services from the American Chemical Society

*By submitting this form, you agree to receive more information on related products and services from the American Chemical Society (ACS Publications) and its sponsor via email. ACS takes your privacy seriously. For more information, please see the ACS Privacy Policy.

View On Demand Webinars