Novel Peptide Hit Identification and Lead Generating Strategies for Drug Discovery

DATE

April 29, 2021

TIME

8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST - Duration: 60 Minutes

Overview

Long recognized as key mediators of important biological effects, peptides hold a prominent position in drug discovery. Peptides can function, for example, as antibiotics, modulators of signaling pathways, inhibitors of protein-protein interactions, as well as smaller, synthetic analogs of biologics; in aggregate, they promise to enable new opportunities for therapeutic intervention.

Join this webinar to:

Compare existing strategies for peptide hit discovery with next-generation approaches for producing, displaying, encoding and screening libraries to identify high-affinity binders with strong functional activity.
Review application of concomitant advances in the generation and incorporation of non-natural building blocks and PEGylation, as well as the introduction of constrained secondary structure elements, such as a macrocyclisation
Discuss advanced synthesis and SAR development techniques

Brought to you by:

Speakers

Andrew Roughton
Executive Director Medicinal Chemistry, RSD,
WuXi AppTec

Graham Ogg
Professor,
MRC Weatherall Institute of Molecular Medicine,
University of Oxford

Hui Liao
Associate Director,
Chemistry Service Unit (CSU),
WuXi AppTec

Ann Thayer
Contributing Editor,
C&EN Media Group

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