Affinity Selection Technologies for Hit Finding: Current State of the Art

DATE

September 8, 2022

TIME

8:00 a.m. PDT, 11:00 a.m. EDT, 17:00 CEST

Duration: 60 Minutes

Overview

The identification of new chemical matter represents a critical step in the early stages of a drug discovery project. An increasingly broad collection of platforms are available to perform this task, some more suited to small, focused screening sets and some more adapted to very large screening sets. Recently traditional high-throughput biochemical assays with a functional read-out have been supplemented by a range of assays based on biophysical methods that address the physical interaction between ligand and protein, but are agnostic of the functional consequence (if any).

In this webinar we will focus on those techniques that seek to identify small molecule binders to target proteins using such ‘affinity selection’ methods. We will discuss the current state of the art for screening of fragments, small screening collections, and ultra-large diversity collections using techniques such as NMR, affinity selection mass spectrometry, and DNA-encoded library screens.

Key Learning Objectives:

Review techniques that seek to identify small molecule binders to target proteins using such ‘affinity selection’ methods
Explore the current state of the art for screening of fragments, small screening collections, and ultra-large diversity collections using techniques such as NMR, affinity selection mass spectrometry, and DNA-encoded library screens.

Who Should Attend:

Drug discovery scientists in academia
Drug discovery scientists in biotech and pharmaceutical industry
Chemists
Biologists
Pharmacologists
Bioanalytical Scientists
Biophysical Scientists

Brought to you by:

Speakers

Dave Madge
Vice President
WuXi AppTec

Alex Satz
Senior Director, DEL Strategy
WuXi AppTec

Grzegorz Popowicz
Head, Helmholtz Institute

Penny Jia
AS-MS Project Leader
WuXi AppTec

Ann Thayer
Contributing Editor
C&EN Media Group

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Yes, we are interested in using (check all that apply):

Affinity selection mass spectrometry (ASMS) as a tool for identifying small molecules.

NMR-based screening strategies to discover high-affinity ligands for our target.

DNA-encoded library (DEL) technology as an ultra-high-throughput screening approach.

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