Real-Time Analysis of Product Attributes in Downstream Processing of Viral Vectors

DATE
March 7, 2023
TIME
8:00 a.m. PST / 11:00 a.m. EST / 16:00 GMT / 17:00 CET - Duration: 60 Minutes

Overview

One of the key challenges during process development and production of biologics is the timely determination of essential product attributes. Rapid feedback of product-relevant characteristics simplifies and accelerates process development and scale-up, then helps ensure product yield and quality during full-scale manufacturing.

We present the use of real-time multi-angle light scattering (RT-MALS) as a process analytical technology to optimize process development of viral vectors. RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles. The application of RT-MALS in downstream processing of viral vectors is shown and discussed. 

Key Learning Objectives:
  • Introduction to real-time MALS (RT-MALS) 
  • How RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles
  • Application of RT-MALS for viral vectors  
Who Should Attend:
  • Bio/pharmaceutical scientists responsible for process analytical technology (PAT), downstream processing, process development and production of biologics
  • Process engineers seeking solutions for monitoring viral vectors or nanoparticle production processes

Brought to you by:
Wyatt Technology Logo

Speakers

Dr. Clara Pérez Peinado
Senior Scientist, Biophysics and Process Analytics Team,
Janssen Vaccines & Prevention B.V
Dan Some, Ph.D.
Principal Scientist,
Wyatt Technology Corp.
Kelly McSweeney
Contributing Editor,
C&EN Media Group

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