Rapid process development and scale-up of novel complex drugs requires advanced PAT tools, capable of providing timely feedback on product attributes. Real-time multi-angle light scattering (RT-MALS) determines key biophysical product attributes, including molar mass, particle size and particle concentration. These attributes are further indicative of quality attributes such as aggregation, identity or titer, and may be used for optimized process control as well as quality monitoring.
This webcast will review the principles, capabilities and limitations of RT-MALS, and then present case studies covering downstream processing (DSP) of proteins, polysaccharides, viruses and lipid nanoparticles.
Key Learning Objectives:
- How RT-MALS measures biophysical product attributes
- How RT-MALS integrates with processing equipment such as FPLC, TFF, reactors and homogenizers
- How RT-MALS optimizes DSP control by monitoring properties of the product, rather than of the process
Who Should Attend:
- Downstream process development scientists in need of real-time analysis to accelerate development time and minimize off-line sample analyses
- PAT technologists exploring the latest methods for DSP product attribute monitoring
- Manufacturing engineers designing PAT-ready production facilities