Characterization of Lipid Nanoparticle Drug Formulations


  • Date
    January 28, 2020
  • Time
    8:00 a.m. PST / 11:00 a.m. EST / 16:00 GMT / 17:00 CET - Duration: 60 Minutes

Date : January 28, 2020
Time : 8:00 a.m. PST / 11:00 a.m. EST / 16:00 GMT / 17:00 CET - Duration: 60 Minutes
  • Overview

    One of the primary challenges in developing and commercializing novel nanoparticle-based therapies is detailed characterization of the formulation components. FFF-DLS-MALS technology, which couples light scattering and other online detectors to field-flow fractionation, addresses this challenge. This webinar will explore applications of FFF-DLS-MALS to characterize nanoparticle drug- and gene-delivery formulations, to determine high-resolution size distributions, drug loading and release, and particle structure.

    The focus of the webinar will be colloidal lipid-based formulations, such as nanoemulsions and liposomes, that can be used to formulate poorly-water-soluble drugs in aqueous preparations to facilitate intravenous administration. FFF-DLS-MALS provides a very useful analytical tool to investigate the behavior of such formulations, even in complex physiological media such as serum. Case studies to be presented include: measurement of detailed liposome size distributions; assessment of drug release and transfer to cell membrane proxies; particle morphology; quantification of co-existing colloidal structures; and stability of the nanocarriers. The relevance of FFF-DLS-MALS to meeting FDA requirements for liposome formulations will be discussed.

    Sponsored by:


    Wyatt Technology

  • Speakers

    Judith Kuntsche, Ph.D.
    Associate Professor
    University of Southern Denmark
    Christoph Johann, Ph.D.
    Global Product Manager
    Wyatt Technology
    Kelly McSweeney
    Contributing Editor
    C&EN Media Group