Stability Characterization of Vaccines and Gene Vectors with Light Scattering

May 24, 2022
8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST
Duration: 60 Minutes


Characterizing quality attributes and other characteristics of biologics, vaccines, and gene vectors is essential at each stage of its discovery, development, production, and quality control. Analytical techniques based on light scattering have become powerful tools for characterizing various attributes include molar mass, size, aggregation, physical titer, thermal and colloidal stability. 

In this webinar, we highlight robust, reliable, simple, quantitative, and fast ways to use three different light scattering techniques - batch dynamic light scattering (DLS), static light scattering (SLS), and massively parallel phase analysis light scattering (MP-PALS) - to characterize the stability of vaccines and gene therapeutic nanoparticles. 

Key Learning Objectives:
  • Basic DLS and MP-PALS theory and instrumentation 
  • How DLS and SLS are applied to study the stability of AAVs and vaccines 
  • How DLS and MP-PALS characterize the stability of lipid nanoparticles 
  • How high-throughput formulation and stability studies are carried out with these techniques 
Who Should Attend:
  • Pharmaceutical scientists involved in analytical characterization and formulation of proteins, monoclonal antibodies, and gene therapeutic nanoparticles
  • Scientists and managers in need of robust, reliable, simple, and fast methods for evaluating biophysical properties and stability
  • Managers of academic labs and core facilities developing viral vectors and LNPs

Brought to you by:
Wyatt Technology


Xujun Zhang, Ph.D.
Application Scientist,
Wyatt Technology
Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group


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