Analyzing Protein Developability and Stability at High-Throughput

DATE

June 13, 2023

TIME

8:00 a.m. PDT / 11:00 a.m. EDT / 16:00 BST / 17:00 CEST - Duration: 60 Minutes

Overview

Understanding the biophysical state, quality and properties of biopharmaceuticals is essential in product and process development. However, available material, time and resources are often limiting.

Dynamic light scattering (DLS) is an industry standard technique for protein formulation, particle sizing and stability studies. This webinar will illuminate how high-throughput DLS (HT-DLS), performed in low-volume microwell plates, is used to understand aggregation as well as colloidal and thermal stability of therapeutic protein candidates and formulations. Application examples include various studies of freeze-thaw, formulation buffer screening and thermal stability.

Key Learning Objectives:

Background and instrumentation for HT-DLS
How DLS is used to study aggregation under applied stresses
How DLS evaluates protein colloidal stability via second virial coefficient A₂ and the diffusion interaction parameter k_D.

Who Should Attend:

Biopharma product development scientists in need of automated methods for characterizing protein stability
Formulation lab managers seeking to improve productivity with high-throughput DLS instrumentation

Brought to you by:

Speakers

Felix Gloge, Ph.D.
Field Application Scientist,
Wyatt Technology

Christian Sieg, Ph.D.
Application Scientist,
Wyatt Technology

Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group

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