Non CYP-Mediated Metabolism Pathways & In Vitro Evaluation Strategies

DATE

February 8, 2022

TIME

11:00 a.m. PDT / 2:00 p.m. EDT / 19:00 BST / 20:00 CEST

Duration: 60 Minutes

Overview

Although cytochrome P450 (CYP)-mediated metabolism continues to be of major importance for a large proportion of small molecule new drug candidates, various methods in recent decades have accelerated the development of drug candidates with significant non CYP-mediated metabolism. Increased interest in these molecules stems from the efforts to develop drug candidates possibly lacking CYP metabolism liability from the drug interactions and toxicity standpoints. Regulatory agencies still have a safety interest in understanding the biochemical pathways involved in the metabolism of these drugs.

In general, uridine diphosphate glucuronosyltransferases (UGTs) are the most common enzymes involved in metabolism after CYP enzymes, followed by numerous hydrolases, carbonyl reductases, aldehyde oxidase and other enzymes. Reaction phenotyping of many of these enzymes is not as straightforward as with CYPs due to their inherent diversity and limited research tools available. The complexity of elucidation of non CYP-mediated metabolism is reflected in regulatory safety requirements.

Key Learning Objectives:

In vitro approaches to evaluate non-CYP enzyme contribution to new drug candidates
Strategies to address non-CYP related metabolism questions in your drug’s safety assessment
Case examples

Who Should Attend:

All levels of research scientists and drug development leadership would be appropriate
Anyone aiming for successful IND / NDA submission, needing to meet regulatory requests and expectations, desiring to formulate a development plan that is as efficient and cost-effective as possible and mitigates risks of late stage failure
Anyone wanting to better understand the ADME properties and potential DDI risks of their compound

Brought to you by:

Speakers

Andrew G. Taylor, Ph.D.
Services Technical Support,
SEKISUI XenoTech

Catherine Dold
Health & Environment Writer,
C&EN Media Group

Registration

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