ACS Infectious Diseases Pop-Ups Webinar

ACS Infectious Diseases Zoom Pop-Up:

Targeting Bacterial Cell Walls: Antibacterial Discovery and a Novel Assay Platform

WEDNESDAY, SEPTEMBER 15, 2021

10:00AM EST | 9:00AM CST | 8:00AM MST | 7:00AM PST

ACS Infectious Diseases Zoom Pop-Up:

Targeting Bacterial Cell Walls: Antibacterial Discovery and a Novel Assay Platform

Join us on September 15, 2021 at 10AM EST for the second ACS Infectious Diseases Zoom Pop Up “Targeting Bacterial Cell Walls: Antibacterial Discovery and a Novel Assay Platform” with speakers Noel Ferraro, PhD candidate in the Biological Chemistry group of Professor Pires at the University of Virginia, and Yuanyuan Chan, graduate student in the Professor Mobashery & Professor Chang labs at the University of Notre Dame.

The conversation will be moderated by Courtney Aldrich, Professor, University of Minnesota and Editor-in-Chief, ACS Infectious Diseases and Peter Tonge, Professor of Chemistry, Stony Brook University and Associate Editor, ACS Infectious Diseases.

Topics covered in this session:

Structure-activity relationship study of quinazolinones against MRSA.
Development of the novel assay platform SaccuFlow for investigating the native structure of bacterial peptidoglycan

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Speakers :

Noel Ferraro

University of Virginia

Noel Ferraro is a PhD candidate in Dr. Marcos Pires’ research group at the University of Virginia. She received her BS in Chemistry from Moravian College in 2016. Her PhD research has included characterizing the factors that impact accessibility to drug and immune targets on the surface of bacteria and developing a high throughput assay that aims to investigate bacterial cell wall interactions with a range of molecules.

Yuanyuan Qian

University of Notre Dame

Yuanyuan Qian is a rising 5th year graduate student majoring in organic chemistry in the Mobashery & Chang labs at the University of Notre Dame. He earned his BSE in Pharmaceutical Engineering from Shaanxi University of Science & Technology, China and an MS in Medicinal Chemistry from Fudan University, China. He was a Ruth L. Kirschstein National Research Service Award Institutional Training Predoctoral Chemistry-Biochemistry-Biology Interface (CBBI) Program Fellow and he is currently an Eck Institute for Global Health Fellow at Notre Dame. For his graduate studies, he works on the design and syntheses of antibacterials against Gram-positive pathogens such as Staphylococcus aureus and Clostridioides difficile. Part of his research work involves the synthesis and structure-activity relationship study (SAR) of the quinazolinones with activity against MRSA. One leading compound exhibits antibacterial activity of its own and synergizes with the piperacillin-tazobactam (TZP) combination both in vitro and in vivo. The synergy is rationalized by the ability of the quinazolinones to bind to the allosteric site of penicillin-binding protein (PBP) 2a, a novel mechanism for manifestation of antibacterial activity.

Moderators:

Courtney Aldrich

University of Minnesota

and Editor-in-Chief, ACS Infectious Diseases

Peter Tonge

Stony Brook University

and Associate Editor, ACS Infectious Diseases