The current generation of solid core particles for LC analysis were introduced in 2006 and provide higher efficiency separations than equivalently sized fully porous particles. Since then, their use for the analysis of both small and large molecules has increased steadily, in a wide variety of analytical fields, to drive high performance separations and increases in laboratory throughput. This white paper focusses on the application of solid core particles to small molecule analysis. It begins by introducing the concept of solid core particles, their morphology, history of development and current methods of synthesis, before moving on to discuss the theory behind the performance advantages they offer. Finally, example applications that demonstrate how these particles can be used to provide solutions for some of the analytical challenges faced by the modern chromatography laboratory are discussed.