Catalysis for Organic Synthesis

A Cornucopia of Catalytic Commitments to Drive the MSD Portfolio

New photochemical methods in halogen-atom transfer chemistry

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Catalysis with Earth Abundant Metals as an Enabling Tool for Chemical Synthesis

Simplifying Synthesis with Electricity

1. Gao, Y; Zhang, B; He, J; Baran, P. S. Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(sp3)–C(sp3) Cross Coupling. J. Am. Chem. Soc. 2023, 145, 21, 11518-11523 
2. Laudadio, G.; Palkowitz, M. D.; Ewing, T. E.-H.; Baran, P. S. Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry. ACS Med. Chem. Lett. 2022, 13, 9, 1413 – 1420 
3. Hayashi, K.; Griffin, J.; Harper, K. C.; Kawamata, Y.; Baran, P. S. Chemoselective, Metal-free, (Hetero) Arene Electroreduction Enabled by Rapid Alternating Polarity. J. Am. Chem. Soc. 2022, 144, 13, 5762 – 5768 

Unlocking The Photocatalytic Functionalities Of Polycyclic Heteroaromatics Through Oxidation Reactions  

New Strategies and Tactics in Natural Products Synthesis

1. Classen, M. J.; Kicin, B.; Ruf, V. A. P.; Hamminger, A; Ribadeau-Dumas, L.; Amberg, W. M.; and Carreira, E. M. Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade J. Am. Chem. Soc. 2023 doi: 10.1021/jacs.3c11000
2. Bulthaupt, H.; Glatz, F.; Papidocha, S. Wu, C.; Teh, S.; Wolfrum, S.; Balazova, L; Wolfrum, C; Carreira, E. M. Enantioselective Total Syntheses of Cassane Furanoditerpenoids and their Stimulation of Cellular Respiration in Brown Adipocytes" J. Am. Chem. Soc. 2023, doi: 10.1021/jacs.3c07597
3. Papidocha, S. M., Bulthaupt, H.; and Carreira, E. M. Synthesis of Neocaesalpin A, AA, and Nominal Neocaesalpin K; Angew. Chem. Int. Ed., 2023, e202310149.
4. Fadel, M., Carreira, E. M. Enantioselective Total Synthesis of (+)-Pedrolide; J. Am. Chem. Soc. 2023, 145, 8332-8337; doi: 10.1021/jacs.3c02113.
5. Classen, M.; Boecker, M.; Roth, R.; Amberg, W. M.; Carreira, E. M., Enantioselective Total Synthesis of (+)-Euphorikanin A J. Am. Chem. Soc. 2021, 143, 8261-8265.

Catalysis via Gold(I) Carbenes

1. (a) Dorel, R.; Echavarren, A. M. Chem. Rev. 2015, 115, 9028–9072. (b) Echavarren, A. M.; Muratore, M. N.; López-Carrillo, V.; Escribano-Cuesta, A.; Huguet, A.; Obradors, C. Org. React. 2017, 92, 1–288.
2. Scharnagel, D.; Escofet, I.; Armengol-Relats, H.; De Orbe, M. E.; Korber, J. N.; Echavarren, A. M. Angew. Chem. Int. Ed. 2020, 59, 4888–4891.
3. Medina, T.; Sadurní, A.; Hammarback, L. A.; Echavarren, A. M. ACS Catal. 2023, 13, 10751–10755.

Catalysis to increase complexity: stereoselective synthesis of sp3-rich building blocks

1. Selected references: a) Teresa, J.; Velado, M.; Fernández de la Pradilla, R.; Viso, A.; Lozano, B.; Tortosa, M. Chem. Sci. 2023,14, 1575. (b) Nóvoa, L.; Trulli, L.; Parra, A.; Tortosa, M. Org. Lett. 2021, 23, 7434. (c) Nóvoa, L.; Trulli, L.; Parra, A.; Tortosa, M. Angew. Chem. Int. Ed. 2021, 60, 11763. (d) Amenós, L; Novoa, L.; Trulli, L.; Arroyo-Bondía, A.; Parra, A.; Tortosa, M., ACS Catal. 2019, 9, 6583-6587. (d) Amenós, L.; Trulli, L.; Nóvoa, L.; Parra, A.; Tortosa, M. Angew. Chem. Int. Ed. 2019, 58, 3188. (e) Guisan-Ceinos, M.; Martin-Heras V.; Tortosa M. J. Am. Chem. Soc. 2017, 139, 8448-8451.

Asymmetric Peptide Catalysis – From Simple to Complex Environments

Accelerating Advances in Catalysis – Concepts, Insights, Strategies

1. Fricke, C.; Sperger, T.; Schoenebeck, F. Angew. Chem. Int. Ed. 2021, 60, 3355.
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3. Dahiya, A.; Gevondian, A. G.; Schoenebeck, F. J. Am. Chem. Soc. 2023, 145, 7729.
4. Hueffel, J.; Sperger, T.; Funes-Ardoiz, I.; Ward, J.; Rissanen, K.; Schoenebeck, F. Science 2021, 374, 1134.

Peptide and Protein Catalysts with Enzyme-like Properties

Metal- or metal-free? Complementarity towards the sustainable synthesis of complex molecules via C-H functionalization.

1. T. Rogge, N. Kaplaneris, N. Chatani, J. Kim, S. Chang, B. Punji, L. L. Schafer, D. G. Musaev, J. Wencel-Delord, C. A. Roberts, R. Sarpong, Z. E. Wilson, M. A. Brimble, M. J. Johansson, L. Ackermann, Nat Rev Methods Primers 2021, 1, 43.
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Catalytic regulation of chemical reaction networks