C&EN White Paper
Affinity chromatography solutions for commercial adeno-associated virus manufacturing
Brought to you by Thermo Fisher Scientific

Gene therapy has been hailed as a revolutionary approach to prevent or treat diseases ranging from inherited disorders to cancer. One way to deliver DNA therapy to a patient’s cells is using viruses that do not cause disease in humans. Adeno-associated viruses (AAVs) are the viral carriers of choice for many gene therapy applications due to their history of low immunogenicity and good clinical outcomes for patients.

AAV are produced commercially in mammalian and insect cells, which means scalable, efficient purification strategies are critical to meeting quality standards and clinical demand. Affinity chromatography resins designed to broadly capture AAVs, or capture AAV subtypes, provide solutions to help manufacturers overcome purification bottlenecks. Affinity resins that capture non-target viruses can also clear contaminants to ensure AAV products meet clinical purity standards. With efficient processes in place, biomanufacturers can ensure that AAV production does not hinder the pace of gene therapy development.

Key Objectives:
  • Why efficient purification solutions are needed in the AAV manufacturing and gene therapy field
  • How affinity ligands enable specific capture and purification of varied subtypes of AAV
  • How affinity ligands speed steps to clear contamination from non-target viruses and meet quality standards

Brought to you by:
Thermo Fisher Scientific
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