C&EN Whitepaper
Custom chromatography solutions for complex biotherapeutics
Brought to you by Thermo Fisher Scientific

Historically, antibodies have dominated the biotherapeutic market but today newer drug types like proteins, viral vectors, and cell therapies are arriving in the clinic in ever increasing numbers.  This growth of non-antibody biotherapeutics is exposing gaps in the chromatography product range on the market. Customization enables a resin to be designed to match the specific performance requirements for the biotherapeutic being purified.

Key Objectives:
  • Customization is an option for the purification of novel biotherapeutics for which no off-the-shelf solution is available.
  • Customized options exist for affinity chromatography, ion-exchange chromatography, and hydrophobic-interaction chromatography resins.
  • Custom-resin development is a stepwise process, with vendors allowing the option to stop or pause resin development at various points.

Brought to you by:
Thermo Fisher Scientific
Thermo Fisher Scientific
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