How affinity tags are speeding up malaria vaccine development

How affinity tags are speeding up malaria vaccine development

Brought to you by Thermo Fisher Scientific

Overview

The parasite that causes malaria has no clear biological target for researchers to target with a vaccine. Despite decades of development, only one malaria vaccine to date has been approved by the World Health Organization.

Researchers have a pipeline of malaria vaccine candidates in development and clinical trials. Antigens for each vaccine are manufactured using the same blueprint, which includes using a novel purification approach for a biotherapeutic: affinity chromatography.

Producing each antigen with the same affinity tag has enabled the team to streamline purification, keep costs down, and rapidly advance their vaccine candidates into the clinic.

Key Objectives:

How affinity tags can be used to manufacture biotherapeutics for challenging targets, such as malaria vaccines
A string of four amino acids, called a C-tag, can be attached to engineered biomolecules and used as a platform technology to accelerate vaccine development
The C-tag affinity system is a viable technology to produce vaccines compliant with good manufacturing practices

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