Purification and quality control solutions to accelerate vaccine development

Overview

Vaccines are critical for disease protection. Rapid vaccine development will be important to respond to new and emerging diseases, as demonstrated by the COVID-19 pandemic caused by SARS-CoV-2. In the past decade, new vaccine types have been developed and can be adapted for use against numerous diseases. However, each type comes with its own manufacturing challenges. Developing versatile purification and quality control methods can help overcome these challenges and meet global demand for vaccines of all types.

Affinity and non-affinity chromatography resins are critical to achieving the high purity and yield needed to produce effective and ample vaccines. Affinity resins developed based on the variable antigen-binding region (VHH) of camelid heavy-chain only antibodies can improve selectivity in vaccine purification protocols. Having a varied suite of non-affinity resins can further improve purity and yield. Furthermore, the development of rapid and accurate quality control assessments can ensure vaccine components are sufficiently pure throughout the manufacturing process, thus improving process design. This whitepaper from Thermo Fisher Scientific highlights how the combination of versatile chromatography resins and quality control assessments can accelerate vaccine manufacturing processes.

Key Objectivesï¼š

Why affinity and non-affinity chromatography are important for vaccine purification and production
How choice of chromatography resin can influence the manufacturing process
Why quality control measures are critical for ensuring vaccine safety and efficacy
How rapid and accurate quality control assessments can help accelerate vaccine development and production

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