DNA-encoded library (DEL) screening technology is changing the game of hit identification during early-stage drug discovery—by allowing billions of molecules to be tested against a biological target, at the same time and in a single Eppendorf tube. With a vastly increased number of compounds tested, the likelihood of finding a hit goes up. But this isn’t just a numbers game; the chemistry matters, particularly molecular weight. DEL technology is also significantly cheaper per molecule screened compared to traditional compound libraries.
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