C&EN White Paper
A fresh start: How DNA-encoded libraries are reinventing hit identification
Brought to you by X-Chem

DNA-encoded library (DEL) screening technology is changing the game of hit identification during early-stage drug discovery—by allowing billions of molecules to be tested against a biological target, at the same time and in a single Eppendorf tube. With a vastly increased number of compounds tested, the likelihood of finding a hit goes up. But this isn’t just a numbers game; the chemistry matters, particularly molecular weight. DEL technology is also significantly cheaper per molecule screened compared to traditional compound libraries.

Key Objectives:
  • The advantages of DEL screening
  • How DEL screening works
  • How to get the most out of a DEL screen
  • Examples of areas of success:
-Identifying covalent binders
-De novo discovery of orthosteric, allosteric, and exosite modulators
-Targeting GPCR proteins
-Broad therapeutic implications

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