A fresh start: How DNA-encoded libraries are reinventing hit identification

A fresh start: How DNA-encoded libraries are reinventing hit identification

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Overview

DNA-encoded library (DEL) screening technology is changing the game of hit identification during early-stage drug discoveryâ€”by allowing billions of molecules to be tested against a biological target, at the same time and in a single Eppendorf tube. With a vastly increased number of compounds tested, the likelihood of finding a hit goes up. But this isnâ€™t just a numbers game; the chemistry matters, particularly molecular weight. DEL technology is also significantly cheaper per molecule screened compared to traditional compound libraries.

Key Objectives:

The advantages of DEL screening
How DEL screening works
How to get the most out of a DEL screen
Examples of areas of success:

-Identifying covalent binders

-De novo discovery of orthosteric, allosteric, and exosite modulators

-Targeting GPCR proteins

-Broad therapeutic implications

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