This whitepaper aims to provide pharmaceutical researchers a better understanding of the uses and benefits of hybrid silica-based supports in HPLC separations of drug compounds. In a quick, absorbing read that includes commentary from a number of experts in the field, readers can find out how hybrid silica-based chromatography rose to popularity in the pharma lab, and why. The many benefits of hybrid silica materials are compared and contrasted with traditional silica usage, supported by references and examples from end users.