The Zika virus (ZIKV) is a single-stranded, positive-sense RNA virus belonging to the flavivirus genus along with the West Nile virus, dengue virus, yellow fever virus, and tickborne encephalitis virus. Polymers are employed in therapy as polymer−protein conjugates, drug−polymer conjugates, gene delivery systems, drug delivery systems, among other applications. Notably, polymers, both synthetic and natural, are effective antiviral inhibitors as shown in numerous studies. The copolymers synthesized and reported here inhibit ZIKV replication in vitro in mammalian cells at nontoxic concentrations. It is plausible that these complexes will be dispersed in aqueous media, possibly also in the blood plasma, and stabilized via repulsive electrostatic forces.
Maria Nowakowska, et al., Jagiellonian University, Krakow, Poland
ACS Omega 2023, 8, 6875−6883