The constant need to develop more rapid and cost-effective technologies for accurate, sensitive and specific detection in biological samples is a driving force behind the integration of new sample preparation tools, automation and informatics across the bioanalytical workflow. These technologies have potential applications in different fields of research ranging from microbiology, toxicology and medicinal chemistry to the pharmaceutical and cosmetic industries, 1 as well as food and environmental safety. 2 We present the design characteristics, operational features and key advantages of a new digital, time-lapse, bright field technology with demonstrated uses and great potential across a range of applications involving bioanalysis of microbial and mammalian cells.