Overview

Researchers typically avoid using affinity tags in the purification of therapeutic proteins. Recently, one very short affinity tag—just four amino acids long—proved its worth for purifying a malaria vaccine candidate for clinical trials. This has opened the door to a range of novel protein-based malaria vaccine candidates, which are now either in or progressing toward clinical trials.

Key Learning Objective

Example of C-tag being used to accelerate vaccine development

C-tag system is a viable technology for GMP-compliant manufacture of therapeutic proteins

Understanding how the C-tag affinity tag system functions

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