Chromatography Fundamentals for the Analysis and Purification of Biologics

Chromatography Fundamentals for the Analysis
and Purification of Biologics

Brought to you by YMC America, Inc.

Overview

Biologics are here to stay. Those seeing approval have begun extending beyond monoclonal antibodies to include more complex designs such as antibody-drug conjugates. Purification methods vary between biomolecule designs but chromatography is the dominant process.

This whitepaper introduces readers both to the chromatography modes that are typically used for biomolecule purification, and to those used at the analytical scale for quality control purposes.

The dominant purification method for biologics is chromatography. Chromatography is also used for quality control purposes. Introduction to how the following modes of chromatography work and what they are useful for:

Affinity chromatography

Size-exclusion chromatography (SEC)

Ion-exchange (IEX) chromatography

Hydrophobic-interaction chromatography (HIC)

Reverse-phase (RP) chromatography Key YMC America products for all the above five chromatography modes when used for biomolecules

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Chromatography Fundamentals for the Analysis and Purification of Biologics

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